▸创新点1：硅基微流控平台（系统创新）：该平台整合了核酸提取、扩增和检测功能，实现了全流程自动化，显著提高了处理效率和准确性。
▸创新点2：全血中核酸提取（方法创新）：直接在硅基微流控芯片上从全血中提取基因组和病毒核酸，简化了传统繁琐的预处理步骤，提高了提取速度和纯度。
▸创新点3：微PCR快速扩增（技术创新）：利用硅基热反应器进行微PCR，实现了快速且高效的核酸扩增，显著缩短了扩增时间，提高了检测灵敏度。
▸创新点4：芯片间集成检测（系统创新）：通过微PCR与微毛细管电泳的芯片间集成，实现了核酸扩增与检测的无缝衔接，提高了检测的准确性和可靠性。
Abstract
This paper gives a brief overview of silicon-based mi- crofluidic platforms developed over the years by our group for the extraction, amplification, and detection of nucleic acids. Extraction of both genomic and viral nucleic acids from whole blood has been demonstrated on Si-based microfluidics. Rapid amplification has been achieved by polymerase chain reaction in Si-based thermal re- actors (micro-PCR). Detection has been realized by a chip-to-chip integration of the micro-PCR and micro capillary electrophoresis (micro-CE).