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JSSC 2013第5期Image Sensors0.18 µm

A 256 Pixel Magnetoresistive Biosensor Microarray in 018 µm CMOS

一款基于0.18 µm CMOS工艺的256像素磁阻生物传感器阵列,用于超灵敏生物标志物检测。
84 dB动态范围,49 nT/√Hz输入参考噪声
磁阻生物传感器CMOS纳米技术生物标志物检测实时监测
集成256个GMR SV生物传感器的阵列
采用紧凑型ΣΔ调制器实现84 dB动态范围
实时动力学监测替代光学蛋白质微阵列
Abstract
Magnetic nanotechnologies have shown signi ficant potential in several areas of nanomedicine such as imaging, therapeutics, and early disease de tection. Giant magnetoresistive spin-valve (GMR SV) sensors coupled with magnetic nanotags (MNTs) possess great promise as u ltra-sensitive biosensors for diagnostics. We report an integrated sensor interface for an array of 256 GMR SV biosensors designed in 0.18 µm CMOS. Arranged like an imager, each of the 16 column level readout channels contains an a