▸8通道能量高效模拟前端放大器：采用低功耗设计，优化了噪声性能和增益带宽积，显著降低了系统功耗，同时提高了信号采集的精度和稳定性。
▸10位Delta调制SAR ADC：结合Delta调制和逐次逼近寄存器（SAR）技术，实现了高精度和低功耗的模数转换，适用于实时神经信号处理。
▸自适应高压耐受刺激器：设计了一种能够自适应调整输出电压的高压刺激器，确保在不同生理条件下安全有效地进行电刺激，提高了系统的可靠性和适应性。
▸可配置生物信号处理器（BSP）：集成多种信号处理算法，支持实时癫痫检测和电刺激控制，增强了系统的灵活性和功能扩展性。
Abstract
An 8-channel closed-loop neural-prosthetic SoC is presented for r eal-time intracranial EEG (iEEG) acquisition, seizure detection, and electrical stimulation in order to suppress epileptic seizures. The SoC i s composed of eight energy-ef ficient analog front -end ampli fiers (AFEAs), a 10-b delta-modulated SAR ADC (DMSAR ADC), a con figurable bio-signal processor (BSP), and an adaptive high-voltage-tolerant stimulator. A wire- Manuscript received April 22, 2013; revised September 11, 2013; accepted September 12, 2013. Date of publication October 18, 2013; date of current version December 20, 2013. This pap er was approved by Guest Editor Michiel Pertijs. This work was supported in part by the National Science Council (NSC), R.O.C., under Project 102-2220-E-009-001 and by the “Aim for the Top University Plan” of the National Chiao Tung University and Ministry of Education, Taiwan, R.O.C. W . - M .C h e n ,M . - D .K e r ,C . - H .Y a n g ,a n dC . - Y .W ua r ew i t ht h eD e p a r t m e n t of Electronics Engineering and the Institute of Electronics, National Chiao Tung University, Hsinchu 300, Taiwan, and also with the Biomedical Electronics Translational Research Center, Nationa l Chiao Tung University, Hsinchu 300, Taiwan (e-mail: peterwu@mail.nctu.edu.tw; mdker@ieee.org). H. Chiueh and T.-J. Chen are with the Department of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 300, Taiwan, and also with the Biomedical Electronics Translational Research