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A Complete 256-Electrode Retinal
一款完整的256电极视网膜假体芯片,具有高集成度和多种安全特性。
65nm CMOS, 150µm电极间距, 8mm²芯片面积, 70%能效
视网膜假体神经刺激CMOS电极驱动器安全监测
▸创新点1:256个独立可编程电极驱动器,采用65 nm CMOS工艺实现150 µm间距的高密度集成,每个驱动器支持可编程电流输出(测量误差低至20 nA),突破了传统视网膜假体电极数量与精度的限制,属于电路创新与系统架构创新。
▸创新点2:4线差分接口设计(600 kHz载频+100 kbps反向数据),同步实现电源传输与双向数据通信,解决了植入式设备有限互联条件下的高效能量与信息传输问题,属于接口协议创新与系统集成创新。
▸创新点3:多层级安全机制(实时电压合规监测、温度传感、电极自锁、ESD防护),确保在异常工况下自动切断刺激并保护组织,其中电极自锁响应时间<1 µs,属于可靠性设计与生物安全性创新。
▸创新点4:70%整体能效比(含23 mW负载功率)与129 µW/电极的超低功耗特性,通过动态电源管理与高效驱动电路优化,满足长期植入的功耗约束,属于能效优化创新。
Abstract
This paper presents a complete 256-electrode retinal prosthesis chip, which is small and ready for packaging and implantation. It contains 256 separate programmable drivers dedicated to 256 electrodes for flexible stimulation. A 4-wire interface is employed for power a nd data transmission between the chip and a driving unit. Power and forward data are recovered from a 600 kHz differential signal, while backward data are sent at 100 kbps rate simultaneously. The stimulator possesses many stimulation features, supporting various stimulation strategies. Many safety features are included such as real-time monitoring of voltage compliance and temperature, electrode self-locking in the event of out-of-compliance, and ESD protection circuit at every electrode. The chip is fabricated in a 65 nm CMOS process. The electrode driver pitch is 150 µm, and total chip area is 8 mm 2.T h e chip has been extensively tested and all the requirements have been successfully veri fied. The measured DC current error for single driver stimulation without electrode shorting is 20 nA. The average power consumption per electrode with typical stimulus pulse parameters and full-scale output current is 129 µW, inclusive of all standby power. The chip overall power ef ficiency is 70% with 23 mW of power delivered to load.