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A 100 fps Time-Correlated Single-Photon- Counting-Based Fluorescence-Lifetime Im
一款基于130nm CMOS工艺的64x64 SPAD-TDC阵列，实现100 fps荧光寿命成像。
62.5 ps分辨率/64 ns量程/42 Gbps/100 fps
单光子雪崩二极管时间数字转换器荧光寿命成像TCSPCCMOS集成
▸64x64 SPAD与独立TDC集成阵列
▸延迟锁定环TDC架构实现62.5 ps分辨率
▸42 Gbps数据压缩传输路径
Abstract
A fully-integrated single-photon avalanche diode
(SPAD) and time-to-digital conv erter (TDC) array for high-speed
fluorescence lifetime imaging microscopy (FLIM) in standard
130 nm CMOS is presented. This imager is comprised of an array
of 64-by-64 SPADs each with an independent TDC for performing
time-correlated single-photon counting (TCSPC) at each pixe l.
The TDCs use a delay-locked-loop-b ased architecture and achieve
a 62.5 ps resolution with up to a 64 ns range. A data-compression
datapath