← 返回 JSSC 论文列表JSSC 2014第5期RF & Wireless0.13µm
Nanostructured CMOS Wireless Ultra-Wideband Label-Free PCR-Free DNA Analysis SoC Hamed Mazhab Jafari , Student Member , IEEE, Karim Abdelhalim , Student Member , IEEE, Leyla Soleymani, Edward H. Sargent, Shana O. Kelley
一款全集成无线超宽带免标记免PCR的DNA分析SoC芯片，采用纳米结构CMOS技术实现高灵敏度检测。
0.13µm CMOS, 1.2V, 50Mb/s无线传输, 10aM检测限
DNA检测无线SoC循环伏安法纳米电极超宽带
▸创新点1：3D纳米结构金电极阵列 - 采用546个3D纳米结构电极和54个2D金电极，显著提高DNA传感的表面积和灵敏度，实现10 aM的超低检测限（PCR-free），属于传感器结构创新。
▸创新点2：斩波稳定电流传输器动态匹配技术 - 通过动态元件匹配的斩波稳定电流传输器设计，实现8.6 pA至350 nA的线性分辨率，解决了微电流检测中的噪声和漂移问题，属于电路级创新。
▸创新点3：可编程波形发生器超宽扫描范围 - 提供0.1 mV/sec至300 V/sec的扫描速率和1.2 V的最大扫描范围，支持灵活的电化学分析参数配置，属于系统级控制创新。
▸创新点4：基于延迟线架构的超宽带无线发射器 - 集成50 Mb/sec高速数据传输功能，功耗仅400 µW，实现了低功耗无线数据通信，属于通信模块创新。
Abstract
A fully integrated 54-channe l wireless fast-scan cyclic voltammetry DNA analysis SoC is presented. The microsystem includes 546 3D nanostructured and 54 2D gold DNA sensing m i c r o e l e c t r o d e sa sw e l la s5 4p Hs e n s o r s .E a c hc h a n n e lc o n s i s t s of a chopper-stabilized current conveyer with dynamic element matching. It is utilized as the amperometric readout circuit with a linear resolution from 8.6 pA to 350 nA. The on-chip programmable waveform generator provides a wide range of user-controlled rate and amplit ude parameters with a maximum scan range of 1.2 V , and scan rate ranging between 0.1 mV/sec to 300 V/sec. A digital ultra-wideband transmitter based on a delay line architecture provides wireless data communication with data rates of up to 50 Mb/sec while consuming 400 µW. The 3 mm × 3 mm prototype fabricated in a 0.13 µm standard CMOS technology has been validated in prostate cancer synthetic DNA detection with 10 aM label-free PCR-free detection limit. Each c h a n n e lo c c u p i e sa na r e ao fo n l y0 . 0 6m m 2and consumes 42 µW of power from a 1.2 V supply.