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JSSC 2014第10期Medical & Bio0.35 µm CMOS

A High Resolution Interface for Kelvin

提出一种高精度阻抗传感接口芯片,用于电化学和生物传感应用。
15位分辨率,150 ppm温度精度,86-95 dB动态范围
阻抗传感生物传感器ΔΣ解调电化学接口高精度
创新点1:全数字ΔΣ解调技术,采用数字信号处理实现高精度阻抗测量,达到15位分辨率和150 ppm温度精度,显著提升测量准确性和稳定性。
创新点2:四核集成设计,通过多核并行处理提高系统效率,支持多种阻抗配置,动态范围达到86 dB至95 dB,满足复杂应用需求。
创新点3:低功耗高精度,采用0.35 µm CMOS技术实现低功耗设计,同时保持高精度测量,适用于便携式和嵌入式应用场景。
创新点4:独立集成系统,设计为完全独立的集成接口,无需外部复杂仪器,简化了阻抗测量的实现过程,提高了系统的便携性和实用性。
Abstract
Impedance sensing, together with impedance spec- troscopy is a powerful tool detecting charge and mass transfe r phenomena at complex interfaces between materials. It is widely used in electrochemical interfaces characterization and biosensing techniques. Recently, it has been proposed as a reli able readout technique to probe biomolecular interactions on modi fied elec- trodes in enzyme biosensors, DNA biosensors and immunosensors. Unfortunately, the requirements of impedance ch aracterization accuracy, precision and dynamic range demanded by some specific application is usually accompli shed by using cumbersome labora- tory instrumentation. In this paper we present a fully integrated standalone, high precision, low power, 4-core impedance sensing interface to be implemented in the fast-growing application field of the ubiquitous sensing. The interfac e is based on a fully digital approach based on a ΔΣ demodulation that is able to achieve 15 bit of resolution, 150 ppm of temperature accuracy and dynamic ranges varying from 86 dB to 95 dB accor ding to the impedance configuration. The 4-core chip has been implemented in 0.35 µm CMOS technology and occupies an area of 9 mm .