← 返回 JSSC 论文列表JSSC 2019第8期RF & Wireless0.18μm
A Wireless Multi-Channel Peripheral Nerve Signal Acquisition System-on-Chip
一款高度集成的十通道无线神经信号采集SoC，适用于慢性植入式神经假体设备。
0.18μm CMOS, 1.9μV rms输入噪声, 4.0 NEF, 10-bit分辨率, 17.5 ksps, 4.4 mW总功耗
神经信号采集SoC植入式设备无线供电近红外LED
▸创新点1：十通道神经信号采集SoC（系统创新） - 该SoC集成了十个独立的神经信号采集通道，实现了多通道同步采集，显著提高了信号采集效率，适用于复杂的周围神经信号监测，每个通道的输入参考噪声低至1.9 μV rms，噪声效率因子（NEF）为4.0。
▸创新点2：仅需四个片外电容（电路创新） - 通过高度集成的设计，该SoC仅需四个片外电容即可实现完整功能，大幅减少了植入设备的体积和复杂度，使其更适合长期植入应用，整体封装体积仅为3.4 cm³。
▸创新点3：近红外LED传输数字神经信号（方法创新） - 采用近红外LED（NIR-LED）作为无线传输介质，实现了高速（3 Mb/s）且低功耗（总功耗4.4 mW）的数字神经信号传输，避免了传统射频传输的电磁干扰问题。
▸创新点4：电极阻抗测量电路（电路创新） - 集成了高精度电极阻抗测量电路，其幅度误差小于10%，相位误差小于8°，能够实时监测电极-组织界面的阻抗变化，确保信号采集的稳定性和可靠性。
Abstract
The adoption of chronic implantable peripheral nerve-based prosthetic devices is currently hampered by the lack of a highly integrated neural signal acquisition system- on-chip (SoC). We report a ten-channel peripheral nervous system (PNS) electroneurogram (ENG) signal acquisition SoC within an implantable package. Requiring only four off-chip capacitors, this SoC can be co-encapsulated with flexible nerve electrodes and a resonant coil antenna to form a 3.4 cm 3 and 3.9 g implantable device for chronic ENG acquisition. This SoC is inductively powered and controlled through a resonant coil at 22 MHz and transmits the digitized neural signal through a near- infrared LED (NIR-LED). Fabricated in 0.18- μm CMOS, each amplifier channel exhibits an input referred noise of 1.9 μV rms and a noise efficiency factor (NEF) of 4.0 within the signal bandwidth of 5.5 kHz. Each amplifier channel within the SoC is digitized with 10-bit resolution at 17.5 ksps, and the total power consumption (SoC and NIR-LED) is 4.4 mW when the NIR-LED is driven at 3 Mb/s. An electrode impedance measurement circuit with <10% magnitude and <8 ◦ angle error for measuring Manuscript received September 7, 2018; revised December 6, 2018 and February 8, 2019; accepted March 26, 2019. Date of publication May 7, 2019; date of current version July 23, 2019. This paper was approved by Associate Editor Azita Emami. This work was supported by the National Research Foundation Singapore under Grant NRF-CRP-10-2012-01. (Corres