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A 0.5-V Sub-10- μW 15.28-m/√ Hz Bio-Impedance Sensor IC With Sub-1◦ Phase Error Kwantae Kim , Student Member , IEEE, Ji-Hoon Kim , Student Member , IEEE, Surin Gweon, Student Member , IEEE, Minseo Kim , Student Member , IEEE
一种0.5V供电、功耗低于10μW的生物阻抗传感器IC，适用于慢性心衰患者的流体状态监测。
0.5V, 10μW, 15.28-mΩ/√Hz, 4.83 mm²
生物阻抗慢性心衰低功耗相位误差流体监测
▸创新点1：0.5V超低电压供电设计（方法创新）。该设计在65nm CMOS工艺下实现了0.5V供电，显著降低了系统功耗，同时通过创新的低电压电路架构维持了高性能，适用于植入式设备的严格功耗限制。
▸创新点2：亚10μW超低功耗性能（系统创新）。整个传感器IC的功耗低于10μW，通过优化的电源管理和信号处理电路，在极低功耗下实现了高精度的生物阻抗测量，满足了长期植入式监测的需求。
▸创新点3：亚1°相位误差的高精度测量（电路创新）。即使在0.5V供电电压的10%波动和0°C至70°C的温度变化下，相位误差仍低于1°，通过创新的相位检测电路和温度补偿技术实现了这一突破。
▸创新点4：15.28-mΩ/√Hz的输入参考阻抗噪声性能（性能创新）。该传感器IC在低功耗和低电压下仍实现了优异的噪声性能，输入参考阻抗噪声低至15.28-mΩ/√Hz，确保了高精度的生物阻抗测量。
Abstract
Continuous monitoring of fluid status through bio- impedance (Bio-Z) measurement of thoracic magnitude or phase is critical in reducing the mortality of chronic heart failure (CHF) patients. However, the stringent power constraints of implantable devices force the design of Bio-Z sensors to be highly challenging. We present a sub-10- μW Bio-Z sensor IC operating from a 0.5 V-supply, sustaining a sub-1 ◦ of phase error even under 10% of supply and 0 ◦C–70 ◦C of temperature variations. Fabricated in a 65-nm CMOS process, this sensor IC exhibits a 15.28-m/√ Hz of input-referred impedance noise performance, occupying a 4.83 mm 2. Its linearity performance shows that the magnitude and the phase of Bio-Z can be measured within the error of 2% and 0.4 ◦, respectively, given that the magnitude of load impedance is less than 126 , and thus, it is suitable for fluid status monitoring applications. Experimental measurement on the human chest demonstrates its capabilities of thoracic impedance variance (TIV) and impedance cardiography (ICG) monitoring.