Abstract
In this article, we present the design and analysis
of an electrochemical circuit for measuring the concentrations of
therapeutic drugs using structure-switching aptamers. Aptamers
are single-stranded nucleic acids, whose sequence is selected to
exhibit high affinity and specificity toward a molecular target,
and change its conformation upon binding. This property, when
coupled with a redox reporter and electrochemical detection,
enables reagent-free biosensing with a subminute temporal
resolution