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c⃝ 2020 IEEE 3 will significantly impact the precision of the dose delivery. Given this, it is common in clinics to widen the Bragg peak to cover the full target volume, and then add treatment margins to ensure the target is covered with prescription dose, resulting in increased dose to normal tissue. In addition, sub-optimal beam arrangements may be selected to avoid delivering dose to a critical organ just distal to where the proton beam stops. An example of a spread-out Bragg peak (SOBP) and the additional margins added to account for this range uncertainty
研究实时体内剂量监测技术以减少质子治疗中的不确定性。
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实时体内剂量监测质子治疗CMOS平台低功耗单粒子灵敏度
▸毫米级植入式剂量计：通过CMOS技术实现毫米级尺寸的植入式剂量计，满足通过标准活检针植入的需求，显著提升了临床应用的可行性和便捷性。
▸低功耗CMOS平台：采用低功耗CMOS技术集成传感器和读出电路，确保剂量计在植入期间能够长时间工作，同时减少对患者的影响。
▸单粒子灵敏度实时测量：设计具有单粒子灵敏度的剂量计，能够实时测量能量沉积，提供精确的剂量数据，有助于实现更安全和有效的闭环治疗。
▸生物兼容性封装：采用医疗级生物兼容材料进行封装，确保剂量计能够在体内长期植入（1-8周），满足慢性治疗的需求。
Abstract
to
ensure the target is covered with prescription dose, resulting
in increased dose to normal tissue. In addition, sub-optimal
beam arrangements may be selected to avoid delivering dose
to a critical organ just distal to where the proton beam stops.
An example of a spread-out Bragg peak (SOBP) and the
additional margins added to account for this range uncertainty
is illustrated in Fig. 1 (b)).
Real-time in-vivo dosimetry (IVD) ameliorates uncertainty
by measuring the dose delivered in the body,