JSSC 2021第1期Other28nm

A 975-mW Fully Integrated Genetic V ariant Discovery System-on-Chip in 28 nm for

首款支持全流程基因变异发现的28nm SoC，37分钟完成全基因组分析，能效提升1.59万倍。

28nm CMOS, 0.9V, 400MHz, 975mW, 12mm²

基因变异发现系统级芯片下一代测序硬件加速能效优化

▸sBWT短读长映射算法硬件化

▸多任务排序引擎与动态规划处理引擎

▸集成ARC处理器实现高效IO接口

Abstract

This article presents the ﬁrst dedicated system-on- chip (SoC) that supports full data analysis workﬂow for genetic variant discovery for next-generation sequencing (NGS). The SoC implements four major steps: preprocessing, short-read mapping, haplotype calling, and variant calling. By adopting the sBWT-based short read mapping and Genome Analysis ToolKit haplotype caller-based variant calling algorithms, this work achieves a comparable precision as the software solutions. The dedicated hardware