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A 384-Site Chip Platform for Biochemical Applications With Individual Site Precision Temperature Control Michael Coln
一种具有384个独立温控反应位点的芯片平台，用于生物化学应用，实现高精度温度控制。
温度范围25°C–125°C，热串扰低于±0.12°C
芯片平台温控生物化学PID控制DNA纯化
▸384个独立温控反应位点
▸PID反馈温度控制
▸热隔离设计
Abstract
A chip platform for thermally controlled biochem-
istry is presented comprising postprocessed thermally isolated
heated reaction sites atop a application-specific integrated circuit
(ASIC) using proportional-integral-di fferential (PID) feedback
temperature control. The 384 sites can be individually pro-
grammed over 25 ◦C–125 ◦C, with thermal crosstalk below the
±0.12 ◦C precision. Double-strand deoxyribonucleic-acid (DNA)
purification via selective melting is demonstrated, with 70%
retention of p