A 16×16 CMOS Proton Camera Array for Direct Extracellular Imaging of Hydrogen-Ion Activity

📋 论文概要

该论文提出了一种16×16 CMOS质子相机阵列，用于直接细胞外氢离子活动成像。通过单片集成传感器和电子学，实现了小几何尺寸内的大规模传感器阵列，为细胞培养的细胞外pH监测提供了新方法。

💡 主要创新点

• 首次实现16×16 CMOS质子相机阵列，用于直接细胞外氢离子活动成像。
• 利用CMOS技术单片集成传感器和读出电路，实现高密度阵列。
• 提供了一种无标记、实时的细胞外pH成像方法。

🏷 关键词

📄 原文摘要

Over the past twenty-five years, silicon CMOS technology has firmly established itself as the dominant platform in the microelectronics industry. This has resulted in many recent initiatives to fabricate CMOS-based microelectrodes for the stimulation and recording of electrical activity of neurons [1, 2]. CMOS technology offers the potential for monolithic integration of sensors and electronics and it serves as an appropriate platform to facilitate the integration of large arrays of sensors into a small geometry [3]. The extracellular pH of a cell culture is a particularly important indicator of global cellular metabolism [4], but up until now, this property has typically been measured with invasive and expensive techniques such as miniaturized glass microelectrodes, fluorescent ratio imaging microscopy and magnetic resonance spectroscopy. CMOS provides a scalable, low cost, mass manufacturing platform, and offers the potential to develop sensor arrays that can

👥 作者与机构

Mark J. Milgrew, Mathis O. Riehle, David R. S. Cumming

University of Glasgow, Glasgow, United Kingdom