A Release-on-Demand Wireless CMOS Drug Delivery SoC Based on Electrothermal Activation Technique

📋 论文概要

该论文提出了一种基于电热激活技术的无线CMOS药物递送片上系统（SoC），实现了无线控制与药物释放阵列的单片集成。通过电热激活机制，该系统能够按需精确释放药物，解决了传统植入式药物递送装置控制精度不足的问题。

💡 主要创新点

• 首次实现无线控制器/驱动电路与药物递送阵列的CMOS单片集成，形成完整的SoC。
• 采用电热激活技术实现药物的精确、按需释放，提高了治疗参数的控制能力。
• 系统支持无线能量传输和数据通信，适用于植入式生物医学应用。

🏷 关键词

📄 原文摘要

biomedical applications. Although in vitro analytical and diagnostic tools have been the focus of such technologies, in vivo therapeutic and sensing applications have received significant attention in the past few years. Novel implantable drug delivery devices, which can precisely control key therapy parameters, have the potential to increase the efficacy of drug therapy [1]. This paper presents an implantable CMOS drug delivery SoC, in which a wireless controller/actuation circuitry and a drug delivery array are monolithically integrated. Compared with current technologies, the advantages of the proposed device include lower system cost, smaller device size and lower power consumption. This device can be implanted by minimally invasive surgery and is suitable for the localized diagnosis/therapy

👥 作者与机构

Yao-Joe Yang, Yu-Jie Huang, Hsin-Hung Liao, Tao Wang, Pen-Li Huang,

Chii-Wan Lin, Yao-Hong Wang, Shey-shi Lu National Taiwan University, Taipei, Taiwan Recently, micro- and nano-technologies have enabled rapid progress in