⚡ 本页包含 AI 生成的分析内容，仅供参考
本文提出了一种用于纳米生物传感器阻抗测量的片上仪器，实现了attoFarad（10^-18 F）级别的分辨率。该芯片解决了传统阻抗测量系统庞大、速度慢的问题，适用于高速生物分子检测。
Impedance measurements play a fundamental role in biotechnology, serving both as an investigation tool and as a direct detection technique. Tracking impedance over time is extensively used for spatial monitoring, imaging, counting, sizing (Coulter counter) and sorting cells (flow cytometry) both in macro and microfluidic systems [1]. Other than cellular biology, impedance measurements are largely used also in molecular biology to operate affinity molecular biosensors [2], where impedance measurements are used to detect the binding of a target molecule to highly specific biological macromolecules such as antibodies, receptors, enzymes and DNA strands. Downscaling these systems to nanoscale dimensions would offer tremendous advantages as compared to the currently existing macro and microscale counterparts on three essential aspects, namely sensitivity (detection of single molecule binding events), response time (more
Fabio Gozzini, Giorgio Ferrari, Marco Sampietro
Politecnico di Milano, Milan, Italy