CMOS Impedance Analyzer for Nanosamples Investigation Operating up to 150MHz with Sub-aF Resolution

📋 论文概要

本文提出了一种CMOS阻抗分析仪，工作频率高达150MHz，具有亚阿法(sub-aF)分辨率，用于纳米样品研究。它解决了现有台式阻抗分析仪体积大、成本高的问题，满足了宽频率范围阻抗光谱分析的需求。

💡 主要创新点

• 首次在CMOS中实现高达150MHz的工作频率，适用于细胞代谢等高速电学测量。
• 实现了亚阿法(sub-aF)级别的电容分辨率，达到极高的测量灵敏度。
• 通过CMOS集成，显著降低了阻抗分析仪的体积和成本，便于便携应用。

🏷 关键词

📄 原文摘要

Impedance analyzers find an important role in nanoscience and in biological research as a tool to access electrical and physical parameters of the matter as well as to enhance the read-out performance in sensor applications. Needs are emerging to perform impedance spectroscopy on a wide frequency range. Electrical assessment of the cell metabolism, for example, requires a frequency of investigation of about 100MHz for the signal to traverse the cell membrane and to access the cytoplasm [1]. Bench-top impedance analyzers exist that cover such a wide frequency range but they are bulky, expensive and have inadequate resolution for the high impedance shown by many nanosamples and semiinsulating biological molecules. Recent compact analyzers based on custom CMOS chips are mainly focused on low-power solutions with sub-MHz ranges

👥 作者与机构

Giorgio Ferrari, Davide Bianchi, Angelo Rottigni, Marco Sampietro

Politecnico di Milano, Milan, Italy