A 0.18µm CMOS Integrated Sensor for the Rapid Identification of Bacteria

📋 论文概要

本论文提出了一种基于0.18µm CMOS工艺的集成传感器，利用噬菌体触发离子级联感测和电噪声分析技术，在10分钟内快速识别细菌。解决了传统细菌检测方法耗时、设备昂贵、体积大的问题。

💡 主要创新点

• 首次将噬菌体触发离子级联感测与CMOS集成电路结合，实现快速细菌识别。
• 采用电噪声分析技术提高传感灵敏度和选择性。
• 实现了低功耗、小型化的片上集成检测系统。

🏷 关键词

📄 原文摘要

There is widespread demand for a low-cost, rapid, selective and sensitive method for detecting bacteria in medical diagnosis, and food-safety inspection. Traditional methods, such as polymerase chain reaction and cell culture techniques take several hours to days to give accurate results, and require bulky, expensive equipment. Recently, a technology called “sensing of phage-triggered ion cascade’’ has been introduced [1], that uses bacteriophages (phages) as biological detecting elements, along with electricalnoise analysis to identify bacteria in less than 10 minutes. A phage is a type of virus that infects bacteria. They are ubiquitous in nature, easily produced, and do not require special storage or handling conditions. Phage libraries with specificities for a wide variety of bacteria of medical interest are commercially available. Figure 18.4.1 shows an electron micrograph of a T4 phage [4,5].

👥 作者与机构

N. Nikkhoo, C. Man, K. Maxwell, P. G. Gulak

University of Toronto, Toronto, Canada