CMOS Mini Nuclear Magnetic Resonance System and its Application for Biomolecular Sensing

📋 论文概要

该论文提出了一种基于CMOS工艺的微型核磁共振（NMR）系统，通过集成高灵敏度、多功能的射频收发器，实现了对水和生物分子的质子NMR测量。与商用台式NMR系统相比，该系统的灵敏度提高了60倍，尺寸缩小了40倍，重量减轻了60倍，为生物分子传感提供了小型化解决方案。

💡 主要创新点

• 首次将高度灵敏和通用的射频收发器集成到CMOS芯片中，构建微型NMR系统。
• 系统实现了比商用台式NMR系统高60倍的灵敏度，同时大幅缩小尺寸和减轻重量。
• 展示了该微型NMR系统在生物分子传感中的实际应用潜力。

🏷 关键词

📄 原文摘要

system (Fig. 7.3.1), made possible by CMOS integration of a highly sensitive and versatile RF transceiver. The system’s functionality is verified through proton NMR measurements in water and biomolecular sensing. The system is 60× more sensitive, 40× smaller, and 60× lighter than a commonly-used, state-of-theart commercial benchtop NMR system [1]. Before discussing our system, let us, in one paragraph, review the NMR basics. The basic components of an NMR system are (Fig. 7.3.2): a magnet (static magnetic field B0), an RF coil surrounding a sample, and an RF transceiver linked to the coil. If an RF signal with the right frequency ω0 is transmitted to the coil (Fig. 7.3.2, top), the RF magnetic field produced by the coil resonantly excites nuclei spins within

👥 作者与机构

Yong Liu1, Nan Sun1, Hakho Lee2, Ralph Weissleder2, Donhee Ham1, 1

Harvard University, Cambridge, MA Massachusetts General Hospital, Harvard Medical School, Boston, MA 2 This paper reports the smallest complete nuclear magnetic resonance (NMR)