⚡ 本页包含 AI 生成的分析内容，仅供参考
该论文提出了一种无线集成电路，用于同时记录神经元的电信号（如单单元动作电位）和化学信号（如神经递质浓度）。通过时分共享技术，该芯片解决了传统离散记录系统体积大、有线束缚等问题，实现了在清醒动物中进行实时神经监测。
Illinois State University, Normal, IL 1 2 Neurons communicate both electrically and chemically [1]. Extensive effort has been directed at monitoring these signals in awake animals to investigate the neural basis of behavior. While various measurement strategies have been employed in the past, electrophysiology (EPHYS) for single-unit recording [2] and voltammetry for neurotransmitter sensing [3] are established as the two best methods for probing neurotransmission at microscopic scales in real time. Major shortcomings of traditional discrete neural-recording systems, e.g. large dimensions and weight, high power consumption and physical restraint of the animal by tethering to monitoring equipment, have recently been addressed by CMOS integration and are largely overcome for EPHYS [4-6]. However, state-of-the-art ICs employing amperometric detection for neurochemistry [7-9] still lack adequate chemical specificity in a complex biological
Masoud Roham1, Paul A. Garris2, Pedram Mohseni1
Case Western Reserve University, Cleveland, OH