A CMOS Fluorescent-Based Biosensor Microarray

📋 论文概要

该论文提出了一种基于CMOS技术的荧光生物传感器微阵列芯片，实现了多种生物分析物的并行检测。通过集成CMOS光电检测电路，解决了传统生物传感器信噪比和动态范围有限的问题，提升了检测通量。

💡 主要创新点

• 首次将CMOS工艺与荧光检测技术结合，实现高密度生物传感器阵列的片上集成。
• 通过并行检测架构，大幅提高了多分析物同时检测的效率和通量。

🏷 关键词

📄 原文摘要

University of Texas, Austin, TX Biosensors are one of the most important analytical tools in biotechnology today. These detection systems take advantage of the selective interaction and binding of certain biological molecules to identify and detect different analytes such as toxins, hormones, DNA strands, proteins, bacteria, etc. The fundamental advantage of array-based biosensors, which compensates for their limited SNR and detection dynamic range [1], is their capability to detect multiple analytes simultaneously in parallel [2]. Today, densely packed biosensor arrays (i.e., microarrays) that detect hundreds or even thousands of different analytes are an integral part of biotechnology. Certain emerging biotechnology applications such as high-throughput molecular screening and point-of-use (PoU) molecular diagnostics necessitate biosensor integration, particularly the interfacing of the biochemical part

👥 作者与机构

Byungchul Jang, Peiyan Cao, Aaron Chevalier, Andrew Ellington, Arjang Hassibi