⚡ 本页包含 AI 生成的分析内容，仅供参考
本文提出一种基于频率偏移机制的CMOS磁生物传感器阵列，实现了单磁珠级别的高灵敏度检测，且无需外部磁铁，解决了传统磁生物传感器依赖外部磁场而难以集成的问题，为便携式即时诊断系统提供了新方案。
Future Point-of-Care (PoC) molecular-level diagnosis requires advanced biosensing systems that can achieve high sensitivity and portability at low power consumption levels, all within a low price-tag for a variety of applications such as in-field medical diagnostics, epidemic disease control, biohazard detection, and forensic analysis. Magnetically labeled biosensors are proposed as a promising candidate to potentially eliminate or augment the optical instruments used by conventional fluorescence-based sensors. However, magnetic biosensors developed thus far require externally generated magnetic biasing fields [1-4] and/or exotic post-fabrication processes [1,2]. This limits the ultimate form-factor of the system, total power consumption, and cost. To address these impediments, we present a low-power scalable frequencyshift magnetic particle biosensor array in bulk CMOS, which provides singlebead detection sensitivity without any (electrical or permanent) external magnets.
Hua Wang, Yan Chen, Arjang Hassibi, Axel Scherer, Ali Hajimiri
California Institute of Technology, Pasadena, CA