A CMOS Electrochemical Impedance Spectroscopy Biosensor Array for Label-Free Biomolecular Detection

📋 论文概要

该论文提出了一种基于CMOS工艺的电化学阻抗谱生物传感器阵列，用于无标记生物分子检测。它通过集成传感器阵列和读出电路，解决了传统生物传感器信噪比低和检测动态范围受限的问题。

💡 主要创新点

• 提出了一种CMOS集成电化学阻抗谱传感器阵列，实现了多通道并行检测。
• 通过优化电路设计提高了信噪比和检测动态范围，适用于无标记生物分子检测。

🏷 关键词

📄 原文摘要

They take advantage of unique biomolecular interactions to capture and detect specific analytes on a surface. The detection versatility of biosensors has always been their key advantage and it has been demonstrated that they can detect almost any analyte such as DNA, proteins, metabolites, and even micro-organisms. However, the achievable SNR and detection DR of biosensors can be very low. This is due to the fact that the capturing processes in biosensors suffer from a significant amount of biological interference (i.e., non-specific bindings) and biochemical noise which typically necessitate the use of complex biochemical labeling processes and sophisticated detectors [1]. Hence, the main design challenge of biosensors is to increase the SNR and DR while minimizing the complexity of both the assay and the detector. Today, this is the main impediment in point-of-care (PoC) biosensors, particularly in high-performance applications

👥 作者与机构

University of Texas, Austin, TX, Biosensors are one of the fundamental detection platforms in biotechnology.