A Low Noise Current Readout Architecture for Fluorescence Detection in Living Subjects

📋 论文概要

该论文提出了一种用于活体荧光检测的低噪声电流读出架构，旨在解决光学分子成像中微弱荧光信号的检测问题，提高了检测灵敏度。

💡 主要创新点

• 提出了一种低噪声电流读出架构，适用于活体荧光分子成像，能够有效地抑制噪声并提高信号检测精度。
• 实现了对生物体内荧光信号的实时、高灵敏度检测，为早期疾病诊断和治疗监测提供了新方法。

🏷 关键词

📄 原文摘要

Natesh Parashurama1, Sanjiv S. Gambhir1, Bruce A. Wooley1 1 2 Stanford University, Stanford, CA, National Semiconductor, Santa Clara, CA Optical molecular imaging is emerging as a powerful preclinical research tool for investigating and quantifying molecular events in living subjects, with applications including earlier detection of disease, therapeutic monitoring and understanding fundamental biology [1]. For example, imaging the fluorescent molecular probe RGD-Cy5.5, which specifically binds to molecules (αvβ3 integrin receptors) that regulate new blood vessel growth in tumors, can be used to quantify this growth [2]. Capturing the fluorescent signal in living subjects with an implanted biosensor would enable continuous monitoring of tumors in freely moving subjects. Continuous monitoring in the setting of cancer would give valuable information on tumor progression, both in assessing drug efficacy and

👥 作者与机构

Roxana T. Heitz1, David B. Barkin2, Thomas D. O’Sullivan1,