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ISSCC 2012Session 17 · DIAGNOSTIC & THERAPEUTIC TECHNOLOGIES FOR HEALTHMedical & Bio

A CMOS Impedance Cytometer for 3D Flowing Single-Cell Real-Time Analysis with ΔΣ Error Correction

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📋 论文概要

本文提出了一种基于CMOS集成电路与微流控通道的单细胞阻抗流式细胞仪,首次实现了非侵入性、高通量的3D流动单细胞实时分析。通过引入ΔΣ误差校正技术,提高了测量精度,为完整细胞分选器件的构建奠定了基础。

💡 主要创新点

重要性
发表年份
ISSCC 2012

🏷 关键词

阻抗流式细胞术CMOS集成电路单细胞分析微流控ΔΣ误差校正

📄 原文摘要

and haematology for the diagnosis and prognosis of disease. It involves the counting, identification and sorting of cells [1,2]. Conventional bulk measurements [3] require a large volume of blood, which is not desirable for the early detection of a disease, when only a very small percentage of cells contain evidence of the disease. In this paper, we propose, for the first time, a non-invasive and high-throughput single-cell analysis method using CMOS-integrated circuits in conjunction with a microfluidic channel as the first building block of a complete cell-sorting device. The description of the sensing scheme in the impedance cytometer is illustrated in Fig. 17.7.1. The device measures the spectral impedance of individual cells

👥 作者与机构

Kang-Ho Lee , Jeonghun Nam , Sukhwan Choi , Hyunjung Lim ,

Sehyun Shin2, Gyu-Hyeong Cho1 1 1 2 2 1 2 KAIST, Daejeon, Korea Korea University, Seoul, Korea Flow cytometry is an essential cell analysis technology in clinical immunology

分类:Medical & Bio · 年份:ISSCC 2012