CMOS Capacitive Biosensor with Enhanced Sensitivity for Label-Free DNA Detection In addition, the device is also independent of duty asymmetry because the charging and discharging operations are repeated alternately with the same duration in a full cycle. This eliminates the DC drift in the output, resulting in robust and reproducible measurements.

📋 论文概要

本文提出一种基于CMOS工艺的高灵敏度电容式生物传感器，用于无标记DNA杂交检测。通过实时测量阻抗变化，实现了快速、鲁棒的DNA定量分析，无需使用标记分子，适合便携式即时检测应用。

💡 主要创新点

• 采用非法拉第电容检测方法，避免了传统电化学传感器的复杂三电极结构，简化了系统设计。
• 在CMOS工艺中集成高灵敏度电容传感电路，显著提高了DNA杂交检测的信噪比和分辨率。
• 实现了无标记实时检测，降低了成本并提高了检测速度，适用于POCT场景。

🏷 关键词

📄 原文摘要

electrical detection when used to quantify the hybridization of DNA molecules. They show rapid, robust, and inexpensive measurement and compatibility with commercial microfabrication technology. The real-time measurement of the impedance does not require the use of labeling molecules attached to the target DNA in optical and magnetic technology [1,2]. It also has the advantage of miniaturization for point-of-care (PoC) or on-site sensing applications, unlike the 3-electrode topology in electrochemical sensors [3]. Several studies have proposed capacitive biosensors that utilize a nonfaradaic process, which refers to transient currents charging a geometrical capacitor in an electrolyte-electrode interface [4]. Conventional capacitive biosensors using the excitation of the bidirectional current [5,6] can be implemented with a compact design, but they have

👥 作者与机构

Kang-Ho Lee, Sukhwan Choi, Jeong Oen Lee, Jun-Bo Yoon, Gyu-Hyeong Cho

KAIST, Daejeon, Korea Silicon devices based on impedance measurements offer label-free and direct