A CMOS 10kpixel Baseline-Free Magnetic Bead Detector with Column-Parallel Readout for Miniaturized Immunoassays

📋 论文概要

该论文提出了一种CMOS 10kpixel无基线磁珠检测器，采用列并行读出架构，用于小型化免疫分析。它解决了磁珠检测中极化场引起的巨大基线问题，无需校准即可实现高灵敏度检测。

💡 主要创新点

• 提出无基线检测技术，消除了极化场带来的测量基线，简化了系统复杂度。
• 采用列并行读出架构，实现了10kpixel阵列的高效读出。
• 集成CMOS工艺，实现了小型化、低成本的免疫分析系统。

🏷 关键词

📄 原文摘要

setting remains an unsolved technological challenge. While laboratory instruments rely on enzymatic labels and require complex, difficult-to-miniaturize optics, devices using super-paramagnetic labels have emerged as an attractive alternative for point-of-care systems [1]. The key challenge for all magnetic-bead detection systems [2-5] is the presence of a large measurement “baseline.” Since beads are paramagnetic, a polarization field must be applied in order to excite a magnetic response. This response is ~1000× smaller than the polarization field, necessitating a combination of calibration, reference sensors [2], and temperature stabilization [5] to reject the polarization field. In addition to a low and stable baseline, a practical system should have low measurement time and large

👥 作者与机构

Simone Gambini, Karl Skucha, Paul Liu, Jungkyu Kim, Reut Krigel,

Richard Mathies, Bernhard Boser University of California at Berkeley, Berkeley, CA The specific detection of anti-bodies or proteins in a point-of-care