A Fully Integrated 8-Channel Closed-Loop Neural-Prosthetic SoC for Real-Time Epileptic Seizure Control

📋 论文概要

该论文提出了一款完全集成的8通道闭环神经假体SoC，用于实时癫痫发作控制。通过闭环反馈机制，该芯片能够检测癫痫发作并施加电刺激，从而有效控制癫痫，解决了现有疗法对约25%患者无效的问题。

💡 主要创新点

• 实现了8通道的闭环神经假体SoC，集成了信号检测、刺激和反馈控制，实现了实时癫痫发作控制。
• 采用了全集成设计，无需外部组件，降低了系统功耗和体积，适合植入式应用。
• 通过闭环算法自适应调整刺激参数，提高了治疗效果和安全性。

🏷 关键词

📄 原文摘要

Chi Jeng1, Shun-Ting Chang1, Ming-Dou Ker1, Chun-Yu Lin1, Ya-Chun Huang1, Chia-Wei Chou1, Tsun-Yuan Fan1, Ming-Seng Cheng1, Sheng-Fu Liang2, Tzu-Chieh Chien2, Sih-Yen Wu2, Yu-Lin Wang2, Fu-Zen Shaw2, Yu-Hsing Huang2, Chia-Hsiang Yang1, Jin-Chern Chiou1, Chih-Wei Chang1, Lei-Chun Chou1, Chung-Yu Wu1 National Chiao Tung University, Hsinchu, Taiwan, National Cheng Kung University, Tainan, Taiwan 1 2 Epilepsy is one of the most common neurological disorders. Around 1% of the world’s population is affected, and nearly 25% of the patients cannot be treated by available therapies. Recently, seizure-triggered feedback electrical stimulation has been proved to effectively suppress pathological brain activities [1], but devices with accurate detection and effective stimulation for real-time seizure control are still unavailable. In this paper, a fully integrated 8-channel closedloop seizure-control SoC with entropy-and-spectrum-aided seizure detection

👥 作者与机构

Wei-Ming Chen1, Herming Chiueh1, Tsan-Jieh Chen1, Chia-Lun Ho1,