An Implantable 455-Active-Electrode 52-Channel CMOS Neural Probe

📋 论文概要

本文设计了一款植入式CMOS神经探针，集成了455个有源电极和52个记录通道，实现了高空间分辨率的多神经元同步监测，解决了传统探头尺寸与分辨率之间的权衡问题。

💡 主要创新点

• 采用高密度455个有源电极阵列，实现亚细胞级空间分辨率。
• 集成52个并行记录通道，支持多脑区同时电生理监测。
• 使用CMOS工艺将有源放大电路集成于电极位点，降低噪声并提高信号完整性。

🏷 关键词

📄 原文摘要

Marleen Welkenhuysen1, Wolfgang Eberle1, Carmen Bartic2, Robert Puers2, Refet Firat Yazicioglu1, Georges Gielen2 imec, Heverlee, Belgium, 2KU Leuven, Heverlee, Belgium 1 Several studies have demonstrated that understanding certain brain functions can only be achieved by simultaneously monitoring the electrical activity of many individual neurons in multiple brain areas [1]. Therefore, the main tradeoff in neural probe design is between minimizing the probe dimensions and achieving high spatial resolution using large arrays of small recording sites. Current stateof-the-art solutions are limited in the amount of simultaneous readout channels

👥 作者与机构

Carolina Mora Lopez1, Alexandru Andrei1, Srinjoy Mitra1,