⚡ 本页包含 AI 生成的分析内容，仅供参考
该论文提出了一款用于贴片式透皮给药系统的离子电渗控制器芯片，通过集成双模式阻抗传感器实现了87mA·min的电流控制。解决了传统给药方式疼痛、感染和肝脏首过效应等问题，实现了精确剂量控制和非侵入性药物递送。
Iontophoresis enhances drug penetration non-invasively into body tissue by electrical stimulation [1]. Compared with injection and oral dosage, it has advantages in the ease of use, the minimization of side effects, such as pain, infection and hepatic first-pass effect, and the targeted drug delivery with precise dosage. Especially, the drug dosage can be easily controlled by changing the stimulation current and duration, or the amount of injected charge. Due to these advantages, the iontophoresis has been widely used to treat various diseases, such as pain relief, chronic edema, and rheumatic condition [2] and even to non-medical applications including cosmetics [3]. Recently, patch type iontophoresis systems [4] use only a DC battery without any current controller. They suffer from load impedance variation or supply voltage drop, and as a consequence it cannot precisely control the amount of injected charge jeopardizing the user with
Kiseok Song, Unsoo Ha, Jaehyuk Lee, Kyeongryeol Bong, Hoi-Jun Yoo
KAIST, Daejeon, Korea