A 0.5V 1.27mW Nose-on-a-Chip for Rapid Diagnosis of Ventilator-Associated Pneumonia

📋 论文概要

该论文提出了一种工作在0.5V超低电压、功耗仅1.27mW的“鼻子芯片”（nose-on-a-chip），用于快速诊断呼吸机相关性肺炎（VAP）。通过集成多种传感器和信号处理电路，实现了对VAP病原体的快速检测，有望降低ICU患者的死亡率。

💡 主要创新点

• 首次在0.5V超低电压下实现完整的电子鼻系统，功耗极低，适合便携式诊断。
• 集成了气体传感器阵列和低功耗读出电路，实现了对多种VAP相关挥发物的快速识别。

🏷 关键词

📄 原文摘要

Chia-Ling Chang1, Chia-Min Yang1, Da-Jeng Yao1, Jen-Huo Wang1, Chien-Ming Huang1, Hsin Chen1, Kwuang-Han Chang1, Chih-Cheng Hsieh1, Ting-Hau Chang1, Meng-Fan Chang1, Chia-Min Wang1, Yi-Wen Liu1, Tsan-Jieh Chen3, Chia-Hsiang Yang3, Herming Chiueh3, Jyuo-Min Shyu1 National Tsing Hua University, Hsinchu, Taiwan, Taipei Medical University, Taipei, Taiwan, 3 National Chiao Tung University, Hsinchu, Taiwan 1 2 Ventilator-associated pneumonia (VAP) is the most frequently acquired infection among patients that receive mechanical ventilation in the intensive-care unit (ICU). The mortality rate for VAP lies in the 20-to-50% range and could be even higher in some ICUs. A standard operation procedure to VAP treatment includes a sequence of chest radiography, sputum gram stain, sputum culture, and empiric therapy, initially with antibiotics covering broad pathogens. However, collection of the gram stain and culture of lower respiratory tract specimen is

👥 作者与机构

Kea-Tiong Tang1, Shih-Wen Chiu1, Chung-Hung Shih2,