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提出一种基于CMOS的微流控细胞仪，利用磁性标签替代传统荧光标签进行细胞检测和分类，解决了现有流式细胞仪难以微型化用于即时检测的问题。该芯片集成了磁性传感器和微流控通道，实现了无荧光、低成本的细胞分析。
Ali M. Niknejad, Bernhard Boser University of California, Berkeley, CA Flow cytometry is widely used in medicine for hematology, immunology, chemotherapy and pathology, as well as in food and water safety. While present instruments are predominantly used in laboratory environments, there is a growing and unmet need for devices that can be used in point-of-care (PoC) settings. The main impediments to PoC solutions are the fluorescent labels, which require sophisticated sample pre-processing and calibration to reduce background, and optics that are difficult to miniaturize. Label-free approaches such as reported in [1] eliminate this problem but have limited applications due to a lack of specificity. Substituting magnetic labels avoids this limitation and eliminates the need for preprocessing, but present solutions use μHall sensors [2] or giant-magneto-resistors (GMRs) [3], which are not available in
Pramod Murali, Igor Izyumin, Daniel Cohen, Jun-Chau Chien,