A 10.8ps-Time-Resolution 256×512 Image Sensor with 2-Tap True-CDS Lock-In Pixels for Fluorescence Lifetime Imaging

📋 论文概要

本文提出了一款用于荧光寿命成像的256×512图像传感器，其像素采用2-Tap True-CDS锁相结构，实现了10.8ps的时间分辨率。该传感器解决了传统CCD和SPAD在时间分辨荧光寿命测量中的分辨率与阵列尺寸限制问题。

💡 主要创新点

• 采用2-Tap True-CDS锁相像素结构，实现高精度时间分辨测量，时间分辨率达10.8ps。
• 在256×512大阵列中实现像素级时间分辨，兼顾高分辨率与大成像面积。
• 通过锁相和CDS技术抑制噪声，提升荧光寿命成像的精度和可靠性。

🏷 关键词

📄 原文摘要

Taishi Takasawa1, Yoshimasa Kawata1, Nobukazu Teranishi1, Zhuo Li1, Izhal Abdul Halin2, Shoji Kawahito1 Shizuoka University, Hamamatsu, Japan Putra University, Selangor Darul Ehsan, Malaysia 1 2 Fluorescence lifetime imaging microscopy (FLIM), which is a nondestructive and minimally invasive manner and can therefore be applied to living cells and tissues, is a great analysis tool in fundamental physics as well as in the life sciences. Charge-coupled devices (CCDs) [1] and single-photon avalanche diodes (SPADs) [2,3] are used for time-resolved lifetime measurement. In particular, SPAD-based time-resolved imagers have a high single-photon sensitivity and good noise robustness. However, they consist of a SPAD array with pixel circuitry, time-to-digital converters (TDCs), digital integrators to amplify signals, and readout circuitry. To implement the high photon-counting rate, a large number of TDCs and digital integrators are required. The spatial

👥 作者与机构

Min-Woong Seo1, Keiichiro Kagawa1, Keita Yasutomi1,