A Multimodality CMOS Sensor Array for Cell-Based Assay and Drug Screening

📋 论文概要

该论文提出了一种多模态CMOS传感器阵列，用于细胞基分析和药物筛选。通过集成电学、光学等多种传感模式，实现了对细胞生理活动的实时、高通量监测，解决了传统药物筛选方法效率低、无法个性化评估的问题。

💡 主要创新点

• 首次在单芯片上集成多模态传感（如阻抗、电位、光学）用于细胞分析，可同时获取多种生理参数。
• 采用CMOS工艺实现高密度传感器阵列，支持大规模并行检测，提高了药物筛选的通量和准确性。
• 设计低噪声前端电路和片上信号处理，提升了检测灵敏度与信噪比，适用于微弱细胞信号记录。

🏷 关键词

📄 原文摘要

tissue-specific physiological behaviors under external biochemical stimuli. External biochemical stimuli trigger endogenous cellular mechanisms that produce a cascade of physiological changes, resulting in easily measurable signals [1, 2]. Cell-based assays are widely used for large-scale drug screening in the pharmaceutical industry, where in vitro cultured cells are used to characterize the potency and toxicity of thousands of chemicals, leading to new drug development. This is particularly relevant in individualized medicine as patient-derived cells can test personalized drug responses. However, most current cell-based assays are conducted on single-modality sensors (electrical [3] or optical [4] only), which cannot capture the complexity of multi-parameter physiological responses (Fig.

👥 作者与机构

Jong Seok Park, Taiyun Chi, Jessica Butts, Tracy Hookway,

Todd McDevitt, Hua Wang Georgia Institute of Technology, Atlanta, GA Cell-based assays are powerful tools to characterize cell- or