A Nanogap Transducer Array on 32nm CMOS for Electrochemical DNA Sequencing source follower’s drop. Thick gate devices also relax ESD constraints for the postprocessing steps required to construct the sensors.

📋 论文概要

该论文提出了一种基于32nm CMOS的纳米间隙换能器阵列，用于电化学DNA测序。芯片集成了8个32×32像素阵列，共8192个感测点，通过行译码器和列并行ADC实现高效读出，解决了高密度传感器读出和生物检测的集成问题。

💡 主要创新点

• 在32nm CMOS工艺上集成了纳米间隙换能器阵列，实现了高密度电化学DNA测序感测。
• 采用类似图像传感器的架构，利用行译码器和列并行ADC进行高效读出，并集成了带隙基准和可编程电流源等偏置电路。
• 片上集成控制逻辑、存储器和串行化接口，便于数据采集与传输。

🏷 关键词

📄 原文摘要

Noureddine Tayebi1, Grace M. Credo1, David J. Liu1, Handong Li1, Kai Wu1, Xing Su1, Madoo Varma1, Oguz H. Elibol1 Architecturally each array is arranged like an imager and the chip contains 8 arrays of 32×32 pixels for a total of 8,192 sensing sites. A row decoder selects one row of pixels to be measured with column-parallel ADCs and biasing circuits. The biasing circuitry comprises a bandgap reference and a programmable current source that is mirrored to bias each of the source followers. Control logic, memory, and serialization are implemented on-chip to facilitate readout of the acquired data. All circuits other than the pixels, including the ADCs, are implemented in thin gate devices with level translators between the row decoder and the pixels. Intel, Santa Clara, CA, 2University of California, San Diego, CA, Intel, Hillsboro, OR 1 3 Next generation sequencing (NGS) is a disruptive technology that concurrently

👥 作者与机构

Drew A. Hall1,2, Jonathan S. Daniels1, Bibiche Geuskens3,