Multi-Functional Microelectrode Array System Featuring 59,760 Electrodes, 2048

📋 论文概要

该论文提出了一种多功能的CMOS微电极阵列（MEA）系统，集成了59,760个电极和2048个电生理通道，同时具备阻抗测量和神经递质检测功能。该系统通过结合有源像素和开关矩阵方法，在保持良好噪声性能的同时实现了大规模并行记录。

💡 主要创新点

• 首次在单芯片上集成近6万个电极和超过2000个电生理通道，实现了超高密度并行记录
• 将电生理记录、阻抗测量和神经递质检测三种功能集成于同一微电极阵列系统，提升了测量维度和应用范围
• 通过混合架构（有源像素与开关矩阵）在噪声性能和通道数量之间取得平衡

🏷 关键词

📄 原文摘要

Vijay Viswam, Jelena Dragas, Amir Shadmani, Yihui Chen, Alexander Stettler, Jan Müller, Andreas Hierlemann ETH Zurich, Basel, Switzerland Various CMOS-based micro-electrode arrays (MEAs) have been developed in recent years for extracellular electrophysiological recording/stimulation of electrogenic cells [1-5]. Mostly two approaches have been used: (i) the activepixel approach (APS) [2-4], which features simultaneous readout of all electrodes, however, at the expense of a comparably high noise level, and (ii) the switchmatrix (SM) approach, which yields better noise performance, whereas only a subset of electrodes (e.g.,1024) is simultaneously read out [5]. All systems feature, at most, voltage recording and/or voltage/current stimulation functionalities. Since neuronal signal transmission is (electro-)chemical, and since local fluctuations of ion concentrations, as well as anisotropic and inhomogeneous

👥 作者与机构

Electrophysiology Channels, Impedance and, Neurotransmitter Measurement Units