A 14GHz Battery-Operated Point-of-Care ESR Spectrometer Based on a 0.13µm CMOS ASIC

📋 论文概要

该论文提出了一种基于0.13µm CMOS ASIC的14GHz电池供电点对点电子自旋共振（ESR）光谱仪，用于直接检测活性氧物种（ROS），以研究氧化应激相关疾病。通过集成化设计，实现了便携式、低功耗的ESR检测系统，解决了传统ESR设备庞大且无法现场应用的问题。

💡 主要创新点

• 首次将14GHz ESR光谱仪集成到0.13µm CMOS ASIC中，实现电池供电的点对点检测。
• 通过低功耗设计和片上信号处理，使设备能够在现场直接检测ROS，支持即时诊断。

🏷 关键词

📄 原文摘要

spatial distribution, and even dynamics of paramagnetic species, electron spin resonance (ESR) spectroscopy is one of the most powerful analytical techniques in modern life sciences. Recently, the method has gained significant attention as a tool to study oxidative stress, i.e., a state in which the number of reactive oxygen species (ROS) exceeds the physiological antioxidative potential of the cells, which plays an important role in the development of many chronic diseases as well as acute stress conditions. Although ESR – as the only known method that allows for a direct detection of ROS – presents the “gold standard” for measuring oxidative stress, in today’s clinical routine, only surrogate parameters of oxidative stress are measured, which

👥 作者与机构

Jonas Handwerker, Benedikt Schlecker, Ulrich Wachter,

Peter Radermacher, Maurits Ortmanns, Jens Anders University of Ulm, Ulm, Germany Thanks to its unique ability to deliver information about the structure,