Nanowatt Circuit Interface to Whole-Cell Bacterial Sensors

📋 论文概要

该论文提出了一种纳瓦级电路接口，用于与全细胞细菌传感器集成，以检测低水平生物发光。通过设计超低功耗读出电路，解决了传统检测硬件功耗高的问题，使能量收集成为可行方案。

💡 主要创新点

• 提出纳瓦级功耗的生物发光检测电路接口，显著降低系统功耗。
• 实现与全细胞细菌传感器的集成，支持自主式小分子检测。

🏷 关键词

📄 原文摘要

emerging as a platform for small molecule detection in challenging environments [1]. A key barrier to widespread deployment of autonomous bacterial sensors is the detection of low-level bioluminescence, which is typically quantified with powerhungry (watt-level) detection hardware such as Photo Multiplier Tubes (PMT). Prior work has reported successful integrated mW-level detection of bioluminescence by using PN / PIN photodiodes with OTA-based [2] and activepixel-sensor circuits [3,4]. Our goal was to develop an even lower power readout to enable harvesting as a viable source of energy for a future batteryless autonomous biological sensor node, with applications in distributed remote environmental sensing, or in vivo biochemical sensing.

👥 作者与机构

Phillip Nadeau1, Mark Mimee1, Sean Carim2, Timothy K. Lu1, Anantha P. Chandrakasan1

Massachusetts Institute of Technology, Cambridge, MA University of California, Berkeley, CA 1 2 Genetically engineered, re-programmable bacterial cells are fast