A Programmable Sub-Nanosecond Time-Gated 4-Tap Lock-In Pixel CMOS Image Sensor for Real-Time Fluorescence Lifetime Imaging Microscopy

📋 论文概要

本文提出了一种可编程亚纳秒时间门控4-tap锁相像素CMOS图像传感器，用于实时荧光寿命成像。该设计解决了传统FLIM系统体积大、速度慢的问题，实现了亚纳秒级时间分辨率的实时成像。

💡 主要创新点

• 提出4-tap锁相像素结构，实现亚纳秒时间门控，提高了时间分辨率。
• 可编程时间门控功能，支持灵活调整门控窗口，适用于不同荧光寿命测量场景。
• 实现了实时荧光寿命成像，无需复杂的后处理，适用于生物医学应用。

🏷 关键词

📄 原文摘要

effective methods in life science and medicine. Among others, fluorescence lifetime imaging microscopy (FLIM) is one of the representative measurement techniques for biomedical applications. Recently, advanced all-solid-state imaging devices for FLIM, e.g., a CCD with optional electron-multiplication (EM) readout, a single-photon avalanche diode (SPAD), and a TR CMOS image sensor (CIS), have been reported [1-3]. These devices can be implemented compactly in comparison with the typical FLIM systems such as a time-correlated singlephoton counting (TCSPC) system [4]. However, imaging devices based on the CCD or SPAD still have some issues, including the need for specialized fabrication processes, use of higher voltages, and greater circuit complexity. The recent TR

👥 作者与机构

Min-Woong Seo, Yuya Shirakawa, Yuriko Masuda, Yoshimasa Kawata,

Keiichiro Kagawa, Keita Yasutomi, Shoji Kawahito Shizuoka University, Hamamatsu, Japan Fluorescence-based time-resolved (TR) analysis techniques are fundamental and