⚡ 本页包含 AI 生成的分析内容,仅供参考
本文提出一种基于双谐振变压器的无参考磁传感器,用于生物检测应用。该传感器通过漂移消除技术实现了0.3ppm的高精度,避免了荧光标记的漂白问题,并兼容CMOS工艺,降低了成本。
Cost-efficient, point-of-use diagnostics are critical for early disease detection. Traditionally, the majority of lab-based analysis equipment utilizes fluorescent markers for biodetection assays. However, magnetic-based labels have recently been shown to be promising alternatives to fluorescent tags for DNA, protein, and cell assays. Magnetic assays offer several key advantages over their fluorescent counterparts, namely that magnetic beads do not suffer from signal decay due to bleaching and that they can be detected with cheap CMOS-based sensors, eliminating the need for expensive lasers, photo-diodes, filters, and complicated post-processing steps. Significant progress has recently been made in the design of magnetic imager ICs, such as [1] which utilizes a GMR approach for detection and [2-4] which measure the resonance shift in an LC tank. While LC-based approaches arguably offer the simplest and cheapest approach
Constantine Sideris, Parham Porsandeh Khial, Bill Ling, Ali Hajimiri
California Institute of Technology, Pasadena, CA