50nW 5kHz-BW Opamp-Less ΔΣ Impedance Analyzer for Brain Neurochemistry Monitoring

📋 论文概要

该论文提出了一种用于脑神经化学监测的超低功耗阻抗分析仪，采用无运算放大器的ΔΣ调制器架构，实现了50nW功耗和5kHz带宽。该设计通过优化电路结构显著降低了功耗，适用于实时监测钾、钠离子浓度等神经化学信号。

💡 主要创新点

• 采用无运算放大器（Opamp-Less）的ΔΣ调制器架构，消除了传统运放的高功耗瓶颈，实现了极低功耗（50nW）。
• 针对脑神经化学监测设计，集成阻抗分析功能，在5kHz带宽内保持良好性能，适用于离子浓度检测。

🏷 关键词

📄 原文摘要

Suzie Dufou1,2, Peter L. Carlen1,2, Michael Thompson1, Roman Genov1 University of Toronto, Toronto, Canada Toronto Western Hospital, Toronto, Canada 1 2 Potassium (K+) and sodium (Na+) ions are the main signal carriers in the nervous system. The difference in the concentration of both K+ and Na+ across the neuron cell membrane, as regulated by respective ion channels, plays a critical role in the propagation of action potentials, the spike-like signals neurons communicate with, as shown in Fig. 17.5.1 (top, left and middle). Due to their significant role in neuronal signaling, K+ channel malfunctions are linked to over 100 neurological disorders, such as schizophrenia, Alzheimer’s disease, spreading depression, and epilepsy. Selective real-time sensing of K+ concentration (denoted as [K+]) is therefore critical for the advancement of many neurological therapies. Conventional intracranial electroencephalography (iEEG) does not measure [K+]

👥 作者与机构

Maged El Ansary1, Nima Soltani1, Hossein Kassiri1, Ruben Machado1,