A 330μm×90μm Opto-Electronically Integrated Wireless System-on-Chip for Recording of Neural Activities

📋 论文概要

该论文提出了一种330μm×90μm的光电集成无线片上系统，用于记录神经活动，解决了传统电极有线连接或大尺寸RF线圈带来的运动伪影和测量限制问题。

💡 主要创新点

• 实现了超小型化（330μm×90μm）的光电集成无线系统，适用于小型生物如斑马鱼和果蝇的神经活动记录。
• 通过光电集成技术，避免了传统电极的物理连接，减少了脑组织与电极之间的相对运动干扰。

🏷 关键词

📄 原文摘要

Paul L. McEuen, Alyosha C. Molnar Cornell University, Ithaca, NY Recording neural activity in live animals in vivo poses several challenges. Electrical techniques typically require electrodes to be tethered to the outside world directly via a wire, or indirectly via an RF Coil [1], which is much larger than the electrodes themselves. Tethered implants result in residual motion between neurons and electrodes as the brain moves, and limits our ability to measure from peripheral nerves in moving animals, especially in smaller organisms such as zebra fish or fruit flies. On the other hand, optical techniques, which are becoming increasingly powerful, are nonetheless often limited to subsets of neurons in any given organism, impeded by scattering of the excitation light and emitted fluorescence, and limited to low temporal resolution [2]. Here we present the electronics for an untethered electrode unit, powered by, and communicating through a microscale

👥 作者与机构

Sunwoo Lee, Alejandro J. Cortese, Paige Trexel, Elizabeth R. Agger,