⚡ 本页包含 AI 生成的分析内容，仅供参考
提出了一种适用于生物传感的电流测量前端，实现了160dB动态范围和7ppm INL，解决了亚皮安级信号电流在nA-μA背景电流下的高精度测量难题。
Accurate current measurement is crucial in many biosensing applications, such as the detection of neurotransmitters [1] and the monitoring of intercellular molecular dynamics. This need has become even more critical recently with single-molecule biosensors where sub-pA signal currents are superimposed on a slowly varying nA-to-μA background current, as is the case with nanopores [2]. As such, the readout circuitry requires wide dynamic range (>120dB) and high linearity (>14b) albeit often with low bandwidth (a few Hz to kHz). This paper presents a current measurement front-end using a modified asynchronous ΔΣ modulator architecture that achieves 7ppm INL and 160dB dynamic range (100fA to 10μA) for a state-of-the-art 197dB FoM due to: 1) a continuous-time, oscillatorbased Hourglass ADC that asynchronously folds the input signal within the supply, 2) noise shaping to suppress the quantization noise, and 3) a digital linearity
Chung-Lun Hsu, Drew A. Hall
University of California, San Diego, La Jolla, CA