A 0.13μm CMOS SoC for Simultaneous Multichannel Optogenetics and Electrophysiological Brain Recording

📋 论文概要

本文设计了一款0.13μm CMOS SoC，实现了多通道光遗传学光刺激与多单元电生理记录在同一芯片上的集成。解决了现有IC无法同时提供多通道光刺激和电生理记录、缺乏ADC或仅支持单一信号模态的问题。

💡 主要创新点

• 首次在同一芯片上集成了多通道光遗传学光刺激和多通道电生理记录功能。
• 芯片集成了ADC，实现了全数字输出的多模态神经信号采集与刺激。

🏷 关键词

📄 原文摘要

approaches in neuroscience to observe neural microcircuits in vivo [1]. Thereby, brain-implantable devices incorporating optical stimulation and low-noise data acquisition means have been designed based on custom integrated circuits (IC) to study the brain of small freely behaving laboratory animals. However, no existing IC provides multichannel optogenetic photo-stimulation along with multiunit electrophysiological recording capability within the same die [2-5]. They also lack critical features: they are not multichannel and/or do not include an ADC [6], or they address only one signal modality [5-6], i.e., either local field potentials (LFP) or action potentials (AP). In this paper, we report an IC for simultaneous multichannel optogenetics and electrophysiological recording addressing both

👥 作者与机构

Gabriel Gagnon-Turcotte, Christian Ethier, Yves De Koninck, Benoit Gosselin

Laval University, Quebec City, Canada Optogenetics and multi-unit electrophysiological recording are state-of-the-art