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本文提出一种毫米级、自由漂浮、无线供电的植入式光学刺激片上系统,用于光遗传神经调控。该系统无需电池或导线,减少了传统有线植入设备对动物行为的限制,提高了行为学研究的准确性。
cell-type specificity, high spatiotemporal precision, and reversibility, optogenetic neuromodulation has been widely utilized in brain mapping, visual prostheses, psychological disorders, Parkinson's disease, epilepsy, and cardiac electrophysiology [1]. While a variety of optical neural interfaces have been developed, most have substantial limitations due to their size and tethering, needed to either deliver light or electricity, which may restrict the animal movements and bias the results, particularly in behavioral studies. In contrast, wirelessly powered optogenetic interfaces improve accuracy, reliability, and validity of the outcomes by eliminating tethers. Recently, a few wirelessly powered optogenetics approaches have been reported with impressive reduction in size of
Yaoyao Jia1, S. Abdollah Mirbozorgi1, Byunghun Lee1, Wasif Khan2,
Fatma Madi2, Arthur Weber2, Wen Li2, Maysam Ghovanloo1 Georgia Institute of Technology, Atlanta, GA Michigan State University, East Lansing, MI 1 2 Thanks to its