A CMOS Biosensor Array with 1024 3-Electrode Voltammetry Pixels and 93dB Dynamic Range

📋 论文概要

该论文提出了一种CMOS生物传感器阵列芯片，集成了1024个三电极伏安法像素，实现了93dB的动态范围。解决了电化学生物传感器在IC设计和传感器表面处理方面的挑战，适用于低成本、可大规模部署的即时诊断设备。

💡 主要创新点

• 首次实现1024像素的三电极伏安法阵列，显著提高了检测通量和空间分辨率。
• 通过电路设计优化，达到了93dB的宽动态范围，能够检测宽浓度范围的生物标志物。
• 采用全电子实时转导方法，无需外部仪器，降低了系统复杂度和成本。

🏷 关键词

📄 原文摘要

Rituraj Singh1, Nader Gamini1, Davood Shahrjerdi2, Robert G. Kuimelis1, Arjang Hassibi1 InSilixa, Sunnyvale, CA New York University, New York, NY 1 2 Electro-analytical (E-chem) biosensors offer unique advantages over widely used optical biosensors and can be considered ideal for low-cost, mass-deployable point-of-care (PoC) diagnostic devices [1]. They possess fully electronic and realtime transduction methods and require little or no external instrumentation. Despite these advantages, two fundamental challenges have hampered broad adoption of E-chem biosensors: IC design and transducer (surface) material suitability. E-chem sensors require both low-noise and high detection dynamic range (DDR) front-end circuits and must also accommodate electrode-electrolyte interfaces with significant PVT variations and temporal drifts [2-5]. The absence of CMOS-compatible bio-electronic interfaces with adequate chemical and thermal

👥 作者与机构

Arun Manickam1, Kae-Dyi You2, Nicholas Wood1, Lei Pei1, Yang Liu1,