A Capacitive Biosensor for Cancer Diagnosis Using a Functionalized Microneedle and a 13.7b-Resolution Capacitance-to-Digital Converter from 1 to 100nF

📋 论文概要

该论文提出一种基于功能化微针的电容式生物传感器，用于癌症诊断。通过检测血管内皮生长因子(VEGF)结合引起的介电性质变化，利用13.7位分辨率的电容-数字转换器实现高精度检测，解决了现有方法需要复杂仪器和繁琐步骤的问题。

💡 主要创新点

• 提出使用功能化微针作为传感界面，可直接与组织接触实现原位检测。
• 集成13.7位高分辨率电容-数字转换器，能够精确检测微小电容变化。
• 针对VEGF生物标志物实现无标记电容式检测，简化癌症诊断流程。

🏷 关键词

📄 原文摘要

dedicated blood supply to provide oxygen and nutrients. Therefore, vascular endothelial growth factor (VEGF), a signal protein produced by cells stimulating angiogenesis, is considered as a key biomarker in clinical diagnosis of cancers [1,2]. There are already existing methods for the VEGF detection requiring advanced instruments and complex protocols [2]. Recently, significant progress has been achieved in biosensors for the detection and quantification of VEGF using synthetic receptors [2]. In particular, a capacitive biosensor detects the change of dielectric properties when the receptor binds to VEGF, and capacitance change can be used to quantify the reactions. However, the sensitivity of the capacitive biosensors still needs to be improved for use in cancer diagnosis.

👥 作者与机构

Seungwoo Song, Jukwan Na, Moonhyung Jang, Hyeyeon Lee,

Hyesoo Lee, Yongbeom Lim, Heonjin Choi, Youngcheol Chae Yonsei University, Seoul, Korea A malignant tumor consists of rapidly growing cancer cells, and requires a