A Fast-Readout Mismatch-Insensitive Magnetoresistive Biosensor Front-End Achieving Sub-ppm Sensitivity

📋 论文概要

该论文提出了一种用于磁生物传感器的快速读出前端电路，通过新颖的失配不敏感技术实现了亚ppm级别的灵敏度，解决了传统生物传感器读出速度慢和易受器件失配影响的问题。

💡 主要创新点

• 提出了一种快速读出架构，能够在不牺牲灵敏度的情况下大幅提高读取速度。
• 采用失配不敏感设计，消除了器件失配对传感器精度的负面影响。
• 实现了亚ppm（百万分之一以下）的灵敏度，适用于高精度磁免疫检测。

🏷 关键词

📄 原文摘要

Magnetic biosensors have drawn significant research interest as a means to replace large optical instrumentation commonly found in centralized diagnostic laboratories. Magnetic biosensing is attractive since biological samples lack a magnetic background thus enabling high sensitivity measurements. Figure 11.4.1 shows a magnetic immunoassay where: 1) the surface of a magnetic sensor is coated with capture molecules (e.g., antibodies) specific to the biomarker (e.g., antigen) of interest, 2) the sample, detection molecules, and magnetic nanoparticles (MNPs) are added and self-assemble thus tethering the MNPs to the sensor, and 3) the sensor is read out by applying a magnetic field, HA, that magnetizes the superparamagnetic MNPs producing a stray field that perturbs the local magnetic field. The underlying magnetoresistive (MR) sensor detects this change in field as a miniscule ppm change in resistance, Rsig, that is directly

👥 作者与机构

Xiahan Zhou, Michael Sveiven, Drew A. Hall

University of California, San Diego, La Jolla, CA