⚡ 本页包含 AI 生成的分析内容，仅供参考
本文提出了一款512像素、3kHz帧率的双shank无透镜无滤波器单光子雪崩二极管（SPAD）CMOS神经成像探针。该探针通过SPAD在Geiger模式外工作，避免了暗计数和不必要的功耗，实现了对荧光信号的高灵敏度检测，解决了传统神经成像系统复杂、功耗高、帧率低的问题。
Laurent Moreaux3, Michael L. Roukes3, Kenneth L. Shepard1 Columbia University, New York, NY KIST, Seoul, Korea 3 California Institute of Technology, Pasadena 1 out of Geiger mode after sufficient decay of the fluorescent signal, avoiding dark count and unnecessary power dissipation. Emitted fluorescent signal intensities from a 15μm microsphere (Thermo Fisher F8844), corresponding to soma dimensions, are measured to be on the order of 1nW. For an isotropic radiating source located 200μm away from the 7.7μm-diameter SPAD, an SNR of 40dB dictates a maximum frame rate of approximately 3kfps. Higher frame-rates, ultimately bounded by the laser repetition rate, are possible under high signallevel conditions. At circuit-level, framerate is bounded by readout overhead requiring two FPGA 100MHz clock cycles per pixel. 2 Optical functional neural imaging has revolutionized neuroscience with optical reporters that enable single-cell-resolved monitoring of neuronal activity in vivo.
Changhyuk Lee1,2, Adriaan J. Taal1, Jaebin Choi1, Kukjoo Kim1, Kevin Tien1,