A Programmable Wireless EEG Monitoring SoC with Open/Closed-Loop Optogenetic and Electrical Stimulation for Epilepsy Control

📋 论文概要

该论文提出了一款可编程无线脑电图（EEG）监测片上系统（SoC），集成了开环/闭环光遗传和电刺激功能，用于癫痫控制。解决了传统电刺激可能伤害神经、电流超限的问题，利用光遗传刺激的优势实现精准神经调控。

💡 主要创新点

• 首次在单芯片上集成可编程无线EEG监测与开环/闭环光遗传和电刺激双模刺激功能。
• 通过光遗传刺激避免电刺激对EEG的人为噪声干扰，并实现特定神经的精准刺激。
• 支持开环和闭环两种刺激模式，可根据EEG信号实时调整刺激参数，提高治疗效果。

🏷 关键词

📄 原文摘要

stimulation systems [1-2] for efficient control of neurological disorders is increasing, because recent clinical studies have shown their efficiency and usefulness in symptom suppression. Electrical stimulation can produce enough stimulation to affect a large range of nerves. However, all nerves near the stimulus are excited and hurt, and over time, currents start to exceed acceptable limits. Therefore, optogenetic stimulation [3-4] has become compelling in recent years due to several advantages: (1) no artificial noise on the EEG; (2) ability to stimulate specific nerves; and (3) no injurious effects on nerves. In this study, a wireless programmable stimulating system-on-chip (WPSSoC) is reported that provides

👥 作者与机构

Shuenn-Yuh Lee, Chieh Tsou, Peng-Wei Huang, Po-Hao Cheng,

Chi-Chung Liao, Zhan-Xien Liao, Hao-Yun Lee, Chou-Ching Lin, Chia-Hsiang Hsieh National Cheng Kung University, Tainan, Taiwan The number of studies on closed-loop detection and electrical